Signaling to NF- B

Signaling to NF - B

colorectal cancer and nf-?b signaling pathway

colorectal cancer (crc) is the second leading cause of cancer death. progress has been made in the development of chemotherapy for advanced crc. targeted therapies against vegf or egfr are now commonly used. however, many cases show that tolerance develops to such treatments; therefore, new strategies are required to replace or complement current therapies. nuclear factor-?b (nf-?b) transcripti...

From Calcium to NF- B Signaling Pathways in Neurons

NFB plays crucial roles in the nervous system, including potential roles in long-term responses to synaptic plasticity, proor antiapoptotic effects during developmental cell death, and neurodegenerative disorders. We report here the characterization of signaling pathways leading to the constitutive activation of NFB in primary cultures of neonatal cerebellar granule neurons, consecutive to calc...

TLR3-mediated NF- B signaling in human esophageal epithelial cells

Lim DM, Narasimhan S, Michaylira CZ, Wang ML. TLR3mediated NFB signaling in human esophageal epithelial cells. Am J Physiol Gastrointest Liver Physiol 297: G1172–G1180, 2009. First published September 24, 2009; doi:10.1152/ajpgi.00065.2009.—Despite its position at the front line against ingested pathogens, very little is presently known about the role of the esophageal epithelium in host innate...

Signaling Role of Intracellular Iron in NF- B Activation*

From the Department of Pathology and Molecular Microbiology and Immunology, Keck School of Medicine of the University of Southern California, Los Angeles, California 90033, the Department of Internal Medicine and Center for Gene Therapy, University of Iowa College of Medicine, Iowa City, Iowa 52242, the Division of Biochemistry and Molecular Biology, University of Southampton, Southampton S016 ...